guanidinosuccic acid

Name	GUANIDINOSUCCINIC ACID
Synonyms	guanidinosuccic acid GUANIDINOSUCCINIC ACID 2-Guanidinosuccinic acid N-AMIDINO-L-ASPARTIC ACID (S)-GUANIDINOSUCCINIC ACID L-ASPARTICACID,N-(AMINOIMINOMETHYL)- (S)-GUANIDINOSUCCINIC ACID dihydrobromide (2S)-2-(diaminomethylideneamino)butanedioic acid
CAS	6133-30-8

Molecular Formula	C5H9N3O4
Molar Mass	175.14
Density	1.74±0.1 g/cm3(Predicted)
Boling Point	344.5±52.0 °C(Predicted)
pKa	3.22±0.23(Predicted)
Storage Condition	2-8°C
In vivo study	Guanidinosuccinic acid, a constituent of normal urine, is elevated in the urine and serum of azotemic patients. Guanidinosuccinic acid (GSA), a guanidino compound found to be greatly increased in uremia, is administered by intraperitoneal (i.p.) injection to adult albino mice and to young mice 7, 14 and 21 days old. Epileptogenic and toxic properties are assessed and Guanidinosuccinic acid brain levels following i.p. injection ae determined. In adult mice, Guanidinosuccinic acid induces long-lasting generalized clonic and clonic-tonic convulsions in a dose-dependent manner with a CD 50 (and 95% confidence interval) of 363 (287-458) mg/kg (n=35), and an LD 50 of 579 (445-756) mg/kg. The CD 50 of Guanidinosuccinic acid corresponded with a brain concentration of 56 nmol/g tissue. Electrocorticographic recording in five adult mice revealed epileptiform discharges (spikes, spike-waves, and polyspike-waves) which appeared concomitant with the convulsions, When young mice are i.p. injected with a (for adults) subconvulsive dose of Guanidinosuccinic acid (250 mg/kg), an age-dependent decrease is noted in Guanidinosuccinic acid-induced convulsions and in the resulting brain concentration.

WGK Germany	3
RTECS	CI9098875

biological activity

Guanidinosuccinic acid is a nitrogen-containing metabolite isolated from serum and urine, elevated in urine and serum of patients with uremia.

Last Update：2024-04-09 02:00:13

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QQ: 3008007409

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